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Evidence-lost to tight glycemic control
Available online /content/12/5/430
Letter
Evidence–lost to tight glycemic control?
Marcus J Schultz1,2,3, Peter E Spronk1,3,4, Ameen Abu-Hanna5, Bekele Afessa6,7
and Ognjen Gajic6,7
1Department of Intensive Care Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
2Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9,
1105 AZ Amsterdam, The Netherlands
3HERMES Critical Care Group, Amsterdam, The Netherlands
4Department of Intensive Care Medicine, Gelre Hospital – Location Lukas, Albert Schweitzerlaan 31, 7334 DZ Apeldoorn, The Netherlands
5Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
6Division of Pulmonary and Critical Care Medicine, Mayo Clinic, First Street 200 Rochester, Minnesota, MN 55905 USA
7Mayo Epidemiology and Translational Research in Intensive Care, Mayo Clinic, First Street 200 Rochester, Minnesota, MN 55905 USA
Corresponding author: Marcus J Schultz, m.j.schultz@amc.uva.nl
Published: 20 October 2008
Critical Care 2008, 12:430 (doi:10.1186/cc7022)
This article is online at /content/12/5/430
? 2008 BioMed Central Ltd
See related research by De la Rosa et al., /content/12/5/R120
In recent years, the field of intensive care medicine has had
the benefit of learning from two randomized controlled trials
that tight glycemic control (TGC) is beneficial to critically ill
patients [1,2]. No benefit was found by two other clinical
trials, however, hampering implementation of TGC in daily
practice [3,4]. The question arises of whether the intensive
care community interprets the results of these later trials in
the correct way. What are the alternative explanations for why
two trials do show beneficial effects while two other trials do
not, apart from the possibility that TGC may indeed not
benefit
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