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Exercise and global well-being in community-dwelling adults with fibromyalgia a systematic review with meta-analysis.doc

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Exercise and global well-being in community-dwelling adults with fibromyalgia a systematic review with meta-analysis

Kelley et al. BMC Public Health 2010, 10:198 /1471-2458/10/198 RESEARCH ARTICLE Open Access Exercise and global well-being in Research article community-dwelling adults with fibromyalgia: a systematic review with meta-analysis George A Kelley*1, Kristi S Kelley1, Jennifer M Hootman2 and Dina L Jones3 Abstract Background: Exercise has been recommended for improving global-well being in adults with fibromyalgia. However, no meta-analysis has determined the effects of exercise on global well-being using a single instrument and when analyzed separately according to intention-to-treat and per-protocol analyses. The purpose of this study was to fill that gap. Methods: Studies were derived from six electronic sources, cross-referencing from retrieved studies and expert review. Dual selection of randomized controlled exercise training studies published between January 1, 1980 and January 1, 2008 and in which global well-being was assessed using the Fibromyalgia Impact Questionnaire (FIQ) were included. Dual abstraction of data for study, subject and exercise program characteristics as well as assessment of changes in global well-being using the total score from the FIQ was conducted. Risk of bias was assessed using the Cochrane bias assessment tool. Random-effects models and Hedges standardized effect size (g) were used to pool results according to per-protocol and intention-to-treat analyses. Results: Of 1,025 studies screened, 7 representing 5 per-protocol and 5 intention-to-treat outcomes in 473 (280 exercise, 193 control) primarily female (99%) participants 18-73 years of age were included. Small, statistically significant improvements in global well-being were observed for per-protocol (g and 95% confidence interval, -0.39, -0.69 to -0.08) and intention-to-treat (-0.34, -0.53 to -0.14) analyses. No statistically significant within-group heterogeneity was found (per-protocol, Qw = 6.04, p = 0.20, I2 = 33.8%; intention-to-treat, Qw = 3.19, p = 0.53, I