Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells.docVIP

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Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells.doc

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ExpressionoftheinflammatorychemokinesCCL5,CCL3andCXCL10injuvenileidiopathicarthritis,anddemonstrationofCCL5productionbyanatypicalsubsetofCD8Tcells

Available online /content/8/2/R50 Research article Open Access Vol 8 No 2 Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells Daniel S Pharoah1, Hemlata Varsani1, Richard W Tatham1, Katy R Newton1, Wilco de Jager2, Berent J Prakken2, Nigel Klein3 and Lucy R Wedderburn1 1Rheumatology Unit, Institute of Child Health, UCL, London, UK 2Department of Paediatric Immunology, Wilhelmina Childrens Hospital, University Medical Centre, Utrecht 3Microbiology/Infectious Disease Unit, Institute of Child Health, UCL, London, UK Corresponding author: Lucy R Wedderburn, l.wedderburn@ich.ucl.ac.uk Received: 4 Oct 2005 Revisions requested: 26 Oct 2005 Revisions received: 16 Jan 2006 Accepted: 6 Feb 2006 Published: 28 Feb 2006 Arthritis Research Therapy 2006, 8:R50 (doi:10.1186/ar1913) This article is online at: /content/8/2/R50 ? 2006 Pharoah et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract This study focuses upon three chemokines, namely CCL5, CXCL10 and CCL3, which are potential novel therapeutic targets in arthritis. The aim of the study was to analyse the expression and production of these three chemokines within the joints of children with juvenile idiopathic arthritis (JIA) of the oligoarticular and polyarticular subtypes. All three of these chemokines are highly expressed at the level of mRNA, with the most significant increase in mRNA levels being demonstrated for CCL5 when compared with matched peripheral blood samples and controls. We show that high levels of all three chemokines are present in synovial fluid of children with JIA. We investigate the