Fetal loss and maternal serum levels of 2,2,4,4,5,5-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p-DDE) exposure a cohort study in Greenland and two European populations.docVIP

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Fetal loss and maternal serum levels of 2,2,4,4,5,5-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p-DDE) exposure a cohort study in Greenland and two European populations.doc

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Fetal loss and maternal serum levels of 2,2,4,4,5,5-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p-DDE) exposure a cohort study in Greenland and two European populations

Toft et al. Environmental Health 2010, 9:22 /content/9/1/22 RESEARCH Open Access Fetal loss and maternal serum levels of Research 2,2,4,4,5,5-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p-DDE) exposure: a cohort study in Greenland and two European populations Gunnar Toft*1, Ane M Thulstrup1, Bo A J?nsson2, Henning S Pedersen3, Jan K Ludwicki4, Valentyna Zvezday5 and Jens P Bonde1,6 Abstract Background: In the present study, the aim is to examine the risk of fetal loss related to environmental 2,2,4,4,5,5- hexachlorobiphenyl (CB-153) or 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p-DDE) exposure. Methods: We related LC/MS/MS measurements of CB-153 and p,p-DDE in serum samples to interview-data on previous fetal loss in populations of pregnant women from Poland, Ukraine and Greenland. Results: In total, 1710 women were interviewed, and 678 of these had at least one previous pregnancy. The risk of ever experiencing a fetal loss increased at higher levels of CB-153 and p,p-DDE exposure, with an adjusted odds ratio (OR) of 2.4; confidence interval (CI) (1.1-5.5) for CB-153200 ng/g lipid compared to 0-25 ng CB-153/g lipid and OR of 2.5 CI (0.9-6.6) for p,p-DDE1500 ng/g lipid compared to 0-250 ng DDE/g lipid. However, no clear dose response associations were observed. The results further suggest that high level of organochlorine serum concentrations may be related to repeated loss. Conclusions: The risk of fetal loss may increase at higher levels of CB-153 and p,p-DDE exposure, although lack of dose response and inconsistencies between countries did not allow for firm conclusions. Background organochlorine pesticides as for example dichlorodiphe- nyltrichloroethane (DDT) are still used, and in these geo- graphical areas, pesticide applicators as well as people living in pesticide sprayed houses are exposed to several fold higher levels of DDT than the general population in the rest of the world [2]. Exposure to per