吴传斌-仿制药高端制剂国际化的研发策略.pptVIP

This is a typical example on aging issue of aqueous film coating. ? Many scientists found that drug release rate from coated dosage form could be changed after stored at room temperature or high temperature. This slide shows the influence of curing time at 40 ?C on the release of theophylline from beads coated with 12% Eudragit RS30D. The curing of coated beads at 40 ?C for 2 days showed a significantly slower release of the drug. This observation indicate the importance of temperature and time effects on complete film formation when coalescence is a slow process. Another issue in aqueous f