静息状态默认脑活动网络的初步检验——视觉呈现语言任务.pdfVIP

中国医学~像技术 2007 年第 23 卷第 6 期 Chin J Med Irnaging Technol. 2007. VoJ 23 .No 6 • 845 • A pilot exploration of resting state brain default mode network hypothesis by usin g f脚fRI: with visually presented language tasks ZHAO Xi ao-hu . LIU } un , WANG Pei-jun , XI Qiαn ， YUN Hong (De卢artment of Radiology. Tongji Hοspítal of Tongji Universíty. Shanghai 200065. Chú国) [ Abstract] Objective By using functionaJ magnetic resonance imaging (fMRl). we p时iminarily test the res ting state brain default mode network hypot hesis and cha racterize the brain regions consis!ing of this ne!work. Methods Thir!een hea lthy volunteers participated in our fMRJ experirnenls. Each subject performed two different language-related task that was visua1- Iy pr臼ented. In experimeot 1 (simple task). subjects were instructed 10 simply fix Ihe non-meaning Chinese words (pseud伊 words) and made silent read for them. In experiment 2 (complicated task). subjects were instructed to produce a verb ∞rre­ spond ing to t he noun that presented on t he screen. During ∞ntrol ∞ndirion. subjects simply fixed on the cr例s. Data were analyzed wi th SPM99 software. We perforrned single subj ect and group averaging analysis individually. We used reverse sub- t racting method to obtain th e group averag旺1 deactivlltion map and lurther explored the characteris tic 01 BOLD single changes in sorne 01 t he deactivated brain regions. R臼ults Our data revealed nearly overlapping deactivated brain pattern between Il1e twO experiments. These brain regions included posterior cingulate and precuneous corlex (PCC. BA 31/30) , amerior cingu - late ∞rtex (ACC , BA 24/32) , bilateral superior temporal gyrus (STG. BA) , bilateral inIerior temporal gyrus (ITG , BA 20) , and bilateral inlerior parietal cortex (BA 39/40) . A