对乙酰氨基酚海藻酸钠壳聚糖微囊的制备及其释药性能的研究.docVIP

芁莅螇螈芇莄袀肄膃莃蕿袆聿莃蚂肂羅莂螄袅芃蒁蒄肀腿蒀薆袃肅葿蚈聿羁蒈袀袁莀蒇薀螄芆蒇蚂羀膂蒆螅螂肈蒅蒄羈羄薄薇螁芃薃虿羆腿薂螁蝿肅薂薁羄肁薁蚃袇荿薀螆肃芅蕿袈袆膁薈薈肁肇膅蚀袄羃芄螂聿节芃蒂袂膈节蚄肈膄芁螆羀肀芀衿螃莈艿薈罿芄艿蚁螂膀芈螃羇肆莇蒃螀羂莆薅羅芁莅螇螈芇莄袀肄膃莃蕿袆聿莃蚂肂羅莂螄袅芃蒁蒄肀腿蒀薆袃肅葿蚈聿羁蒈袀袁莀蒇薀螄芆蒇蚂羀膂蒆螅螂肈蒅蒄羈羄薄薇螁芃薃虿羆腿薂螁蝿肅薂薁羄肁薁蚃袇荿薀螆肃芅蕿袈袆膁薈薈肁肇膅蚀袄羃芄螂聿节芃蒂袂膈节蚄肈膄芁螆羀肀芀衿螃莈艿薈罿芄艿蚁螂膀芈螃羇肆莇蒃螀羂莆薅羅芁莅螇螈芇莄袀肄膃莃蕿袆聿莃蚂肂羅莂螄袅芃蒁蒄肀腿蒀薆袃肅葿蚈聿羁蒈袀袁莀蒇薀螄芆蒇蚂羀膂蒆螅螂肈蒅蒄羈羄薄薇螁芃薃虿羆腿薂螁蝿肅薂薁羄肁薁蚃袇荿薀螆肃芅蕿袈袆膁薈薈肁肇膅蚀袄羃芄螂聿节芃蒂袂膈节蚄肈膄芁螆羀肀芀衿螃莈艿薈罿芄艿蚁螂膀芈螃羇肆莇蒃螀羂莆薅羅芁莅螇螈芇莄袀肄膃莃蕿袆聿莃蚂肂羅莂螄袅芃蒁蒄肀腿蒀薆袃肅葿蚈聿羁蒈袀 对乙酰氨基酚海藻酸钠壳聚糖微囊的制备及其释药性能的研究 王秀丽( 李海云 王天予 （桂林工学院材料与化学工程系，广西，桂林，541004 ） 摘要：壳聚糖与海藻酸钠为囊材对乙酰氨基酚微囊，对乙酰氨基酚微囊采用乳化和相分离法中的复凝聚相结合的方法制备对乙酰氨基酚微囊以载药率为指标，选取海藻酸钠浓度、壳聚糖浓度、氯化钙浓度和对乙酰氨基酚用量4 个因素，选用L9 (34) 表进行正交试验优化制备工艺。采用扫描电子显微镜SEM测试技术对微囊进行形态观察。用激光粒度分析仪测定所制微囊粒度分布和粒度特定参数。采用紫外分光光度法测定药物的包封率、载药率及其释药性能。对乙酰氨基酚微囊最佳制备工艺为海藻酸钠溶液浓度1.5%，壳聚糖浓度0.8%,氯化钙浓度1.5%，对乙酰氨基酚载药比10mg/mL。所制微囊平均粒径为21.32μm，分散度较好，形状较规整，其载药率为23.65%，包封率为76.85%，12h释放了94.3%。对乙酰氨基酚微囊关键词：对乙酰氨基酚；海藻酸钠；壳聚糖；微囊；缓释 文献标识码：A(Department of Material and Chemical Engineering,Guilin University of Technology,Guangxi Guilin,541004 ) ABSTRACT: OBJECTIVE: To study the optimal process of the preparation of microcapsules using chitosan-sodium alginate as wall material and paracetamol as corematerial, and study the sustained-realease effect. METHODS: L9 (34) orthogonal test was carried out to investigate four influential factors for the encapsulation ration of the prepared microcapsules, including sodium alginate , chitosan , CaCl2 and paracetamol. SEM and laser particle sizer were used to analyse the characters, size distribution and feature parameters of diameter distribution of the microcapsules. VIS-UV were used to measure And the envelope efficiency ,the encapsulation ration and release performance of the drug were measured with VIS-UV methods. RESULTS: The optimum conditions of the preparation of microcapsules were solutions of 1.5% sodium alginate, 0.8% chitosan, 10mg/mL paracetamol and 1.5% calcium chloride. The average diameter of the microcapsules was 21.32μm.The encapsulation ration of paracetamol was 23.65% and the degr