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* * PegIFN, peginterferon; RBV, ribavirin. We performed a pilot study to try to answer this question. In this study, difficult-to-treat US patients, namely those with genotype?1 infection, HCV RNA 850,000?IU/mL, and body weight 85?kg, were randomized to a standard regimen of peginterferon alfa-2a 180?μg/wk plus ribavirin 1200?mg/day or to 1 of 3 more intense regimens. In the most intensive regimen, patients received peginterferon alfa-2a 270?μg/wk plus ribavirin 1600?mg/day, and the remaining 2 arms contained either the higher dose of ribavirin or the higher dose of peginterferon alfa-2a,