45110307许超.ppt

“ ” THE APPLICATION AND SAFETY ASSESSMENT OF ASPARTAME 甜味剂阿斯巴甜的使用及其安全性评估 许超 1.The chemical structure of Aspartame Aspartame is made up of L-aspartic acid and condensation of L-phenylalanine dipeptide compound. White crystalline powder, formula for 18 N2O5 C14H, relative molecular mass, 294, 31 pairs of melting point is about 190 and 245, slightly soluble in water and ethanol. aspartame 2. The application of Aspartame Aspartame is an artificial, non-saccharide sweetener used as a sugar substitute in some foods and beverages. Aspartame was discovered in 1965 by James M. Schlatter, a chemist working for G.D. Searle Company. In the European Union, it is codified as E951. Aspartame is a methyl ester of the aspartic acid/phenylalanine dipeptide. It was first sold under the brand name nutrasweet; since 2009 it also has been sold under the brand name aminosweet. It was first synthesized in 1965 and the patent expired in 1992. Aspartame has a strong sweet taste, its dilute solution of about 100 ~ 200 times of sucrose sweetness. Its sweet taste is quite similar with sugar, and have cool and refreshing feeling. And it is easy to be absorbed by human. Because aspartame has many outstanding advantages, it has become the most widely used sweetener, applied in all kinds of food in the world. Some food that add aspartame as sweetener 3. The safety assessment of aspartame Aspartame has been nearly 100 countries approved to use, and many countries have used more than 20 years. In China ,the second food additives standardization technical committee meeting to discuss through the use of aspartame in 1985. The joint FAO/WHO expert committee on food additives (JECFA) and the European commissions scientific committee on food has determined this value is 40 mg/kg of body weight for aspartame, while FDA has set its ADI for aspartame at 50 mg/kg. A 12 US fluid ounce (355 ml) can of diet soda contains 180 milligrams (0.0063 oz) of aspartame, and for a 75 kg (165 lb) ad