生物材料 2 含糖聚合物在基因载体上应用.pdfVIP

Biomaterials 32 (2011) 5279e5290 Contents lists available at ScienceDirect Biomaterials journal homepage: www.elsevi /locate/biomaterials The effect of polymer architecture, composition, and molecular weight on the properties of glycopolymer-based non-viral gene delivery systems Marya Ahmed, Ravin Narain* Department of Chemical and Materials Engineering and Alberta Ingenuity Centre for Carbohydrate Science, University of Alberta, 116 St and 85 Ave, Edmonton, AB T6G 2G6, Canada a r t i c l e i n f o a b s t r a c t Article history: Although a variety of non-viral gene delivery vectors has been synthesized and used for gene delivery Received 21 March 2011 purposes, well-defined glycopolymer-based gene delivery carriers is not well explored. Reversible Accepted 30 March 2011 Addition-Fragmentation Chain Transfer (RAFT) polymerization technique allows successful and facile Available online 6 May 2011 synthesis of cationic glycopolymers containing pendant sugar moieties in the absence of protecting group chemistry. A library of cationic glycopolymers of pre-determined molar masses and narrow Keywords: polydispersities ranging from 3 to 30 kDa has been synthesized using RAFT polymerization technique. RAFT polymerization These polymers differ from each other in their architectures (block versus random), molecular weights,