SUMO化蛋白修饰与肿瘤浸润和转移.pdfVIP

黯际略吸杂志2009 年 1 月第 29 卷第 2 期 Int J Re.pir.January 2009. Vo l. 29.1110.2 • 75 • ·综述. SUMO 化蛋白修饰与肿瘤浸润和转移 冯耘李庆云万欢美 E铺要】 割草转移是指恶性肿瘤细胞脱离原发病灶，然后通过各种转移方式，到达另-(些〉组织和器官 后得以继续繁殖生长，形成性质和原发肿瘤栩同a栩近的续发肿瘤的全过程.网明癌症辛苦移的分子机制有 盖在于发现抑制其浸润转移的新途径.小泛素相关修饰物(SUMO)是-种类泛.化蛋白.可以修饰大囊的转 录因子和共辛苦亲因子.近年来报道了-些 SUMO 化修饰的与肿姻浸调和转移捕关的蛋白质，现对这些发 现及其在痛症转移中的重要生物学作用作一综述. E关键词E 小泛素相关修饰物3 肿痛;浸润s 转移 FUDctÎon of SUMO m创10臼110ft In 姐ncer lnrlltratioo and _1描tasis F艺NG Yun.Ll Qing-yun.WAN Hua n-ying. Department 01 Respiratory Medicine •[Òûjin HosPital.她dical College 01 Shanghai Jiaotong University. Shanghai 200025.αlna Ccrresponding author: ,WAN Huan-yi略，后nail ， η_ILO.nhy@yah∞.rom.cn (Abstract) Cancer metastasis is a pro:ess by which tumor cells spread almost unconlrollably from primary lumOf to form secondary tumors 81 a disl8nt organ in the body. Elucidating Ihe mechanism by which this complex process is conlr01lOO at Ihe molecular level wi 1l be t remendou sly helpful in developing new therapeutic appr08ches for tr制ting metastatic cancer. Small ubiquitin-relaled modifier(SUMO).8 member of ubiq山tin-like protei皿.m臼lifies a large number of transcription factors and coregulator5. It has b回n reported that a number of canc町 metastasi5 associated protein5 undergo SUMOyJation. incJuding 阿ptin. HIF- lα.E15 family . NF-κB. This article overviews Ihese findings and discusses biological importance of pro!ein SUMOyJalion in cancer infiltration and metaslasis. (Key w阳也) SUMO;Tumor; InfiJtration; MelaSlasis 许多调控基因转录的重要蛋白质在基因转录、 素化研究越来越深入，类泛素化修饰的研究也得到 蛋白质翻译及翻译后水平被多种机制所控制以确保 人们的关注，如小泛素相关修饰物(small ubiquitin- related modifier. SUMO)、 Rubll 、 Apg8、 Apg12 细胞内环境的稳定，一旦内环挠的稳态被破坏.常常 等问都具有类似于泛索化的修饰功能，但它们并不 会导致肿燎的发生。蛋白翻译后修饰机制是一个复