XELOX方案与FOLFOX4方案治疗转移性结直肠癌的临床观察.pdfVIP

.1736. MODERN ONCOLOGY •Sep. 2仅涉. VOI. 17 •NO. 09 XELOX 方案与 FOLFOX4 方案治疗转移性结直肠癌的11岳床观察 黄海欣，璋绍镜，李桂生 Clinical study of capecita剖ne plus oxaliplatin compa陪d with 5 -在Jorouracil / leucovorin (LV5FU2) pl吕s oxaliplatin in the treatment of metasfatic colorectaI cancer HUANG Hai- 芷in ， CHEN Shao - jun , U Gui - sheng De严， Ttmenl 01 Medical Dncology， 到e Fourth A..6邵阳:ed Hosp必al 01 GlUJ1喀Xi Medical Uni四Tsity ， Gi皿号Xi μUZMU 545∞5 ， China. [Abs往事ctl Obj仅tive: To 肝必回te the e筒C配歹皿dto对city of capecitahine pl凶 oxaliplatin regimen (XELOX) versus 5 - fluorouraciVleucovorin (LV5FU2) plus oxaliplatin regimen (FOLFOX4) in the t1eatment of me国tatic ∞，10陀C惚1 cancer. Methods: Total of 48 c皿臼 with metastatic colorectal cancer wer军 enrolled into 也is 血句，25 pa- tients and 23 patien恒 were randomly di材ded into XEIρXgro日p and FOLFOX4 grηup I四peclively. XELOX group was 2 2 往回ted withω严烦恼hine 眼泪mgIm d ，肘， BidA_14;oxaliplatin 130 mgIm d , ivgtt , dl . FOLFOX4 gr咽口p was t1，四­ ted with oxaliplatin 85 mgIm2 d ， ivgtt ，也 ;LV2∞ mgl旷 ivgtt 2h followed by 5 - FU 400 mgIm2 ( bolus) 四d5 -FU 600 mgIm2 (22h - coutinous in缸síon). XEIβX regimen W88 r琶严ated every 3 weeks for one cycle ,FOLFOX4 regimen 曹88 re严ated eve巧 2 weeks ,4 weeks for one cycle. AlI patients received two cycles of chemotherapy at least. The e伍­ cacy and toxicity were evaluated accmding to WHO standard. Re姻ts: All48 c皑白 were availahle for objective re- sponse. 切le overall r，回ponse rate was 48. 0% ( CR2 ,PR IO ) in XELOX group of 25 咽ses 朋d 47.8% (CR2, PR9) in FOLFOX4