第二章药动学(国外英文资料).docVIP

第二章药动学(国外英文资料) [test] One, the noun explanation (1) absorption (); Distribution (distribution); The blood-brain barrier; Placental barrier; 5. Drain (excretion); First pass elimination. Hepatoenteal riculation; Bioavailability (bioavailability); Elimination (elimination); Elimination rate constant (ke); Half life, t1/2; The concept of bedroom concept; Apparent volume of distribution (Vd); Steady-state concentration, Css; First orde elimination kinetics; Zero-order elimination kinetics; Load dosage (1oading dose) Second, fills up the topic 1. The process of drug in the body,,, and. 2. The passive transport features are drugs from a side, to the side of the diffusion of transhipment, dont use up, do not need to participate in, not influenced by and. 3. The passive transport through membrane of weakly acidic drugs, the greater the pH value of the transport environment, the mold, the drug solution due to a dissociation is fat soluble, so also the drug through the cell membrane. 4. The influence of the concentration of active transport to film on both sides of the high and low, the consumption of saturated and competitive inhibition. 5. Drugs through biological transformation, the vast majority of product into sex high solubility and from renal excretion. Hepatic enzyme is characterized by low sex and phenomenon. 7. The abbreviation of elimination rate constant is that half-life is the abbreviation of, is the abbreviation of apparent volume of distribution, stable blood concentration is the abbreviation. Third, multiple choice (1) A (1 ~ 42) The way most drugs cross the membrane in the body is: A. active transport B. simple diffusion C. ease of diffusion D. film hole filter E. pinocytosis The following drugs are not affected by the first elimination A. lidocaine B. nitroglycerin C. morphine D. hydrochlorothiazide E. propranolol Bioavailability is an oral drug A. actually give the dosage The speed of absorption C. eliminate the amount of medicine D. absorb the amount of b