第 三 单元 药动学(国外英文资料).docVIP

第 三 单元 药动学(国外英文资料) Unit 3 The outline The process of the drug Drug metabolism The process of the drug Key points: Drug transmembrane transport The absorption, distribution, excretion and the effect of the drug The concept of plasma protein binding and hepatic circulation Common P450 enzymes and their inhibitors and inducers Processes in the drug include absorption, distribution, metabolism, and excretion. metabolism (1) transmembrane transport of drugs Mode: passive transport, active transport and film transfer. Passive transport Features: From one side of the high concentration to the lower part of the concentration, the concentration of the concentration is passed through the biofilm. The transport process does not consume energy, it does not need the carrier, there is no competition between the drugs, there is no saturation. When the concentration of drug on both sides of the biofilm reaches equilibrium, the transshipment stops. Methods: simple diffusion, filtering and diffusion (1) simple diffusion: fat-soluble diffusion Drugs that are small, polar, fat-soluble, and non-ionized are easy to pass through biofilms. The pH of the humoral influences the degree of dissociation of the drug. Weak acid: HA = H + + A - 10 PH - Pka = [A] / [A] [ionotype] Weak alkaline drugs: BH + = h+ B 10 Pka - PH = [BH +] / [B] = [ionotype] Example: a pKa = 8.4 dissociation in plasma A. 10% B. 40% 50% C. D. 60% E. 90% [answer # 5006470101: question the question] The correct answer A The formula for the dissociation of weakly acidic drugs is 10 ph-pka = (dissociation type) The distance is 10, 7.4 minus 8.4 is 10 minus 1 is 0.1. Example: a weak acid drug pKa = 3.4 Press 10 PH - Pka = [A -] / [A]. Gastric juice is alkaline urine PH 1.4, 7.4, 8.4 A minus 0.01, 100,000 HA 1 1 1 A - + HA 1.01, 10001 100001 conclusion Acid drugs in acidic environments are less likely to be removed and easily transshipped. When the diffusion equilibrium is reached, the main distribution is in the base side. Alka