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两种A类氨基酸转运蛋白部分功能差异的研究-中国细胞生物学学报
细胞生物学杂志
104 2003 年
(6880): 545 - 548. 2002 , Stem Ce屿,, 20(3) : 249-258
[ 15] Terada N ,Hamazaki T ,Oka M et 乱 , 2002 , Apr4 Na- [ 17] Reyes M , Verfaillie C旺, 2001 , Jun Ann N Y Acad
tu时,416( 6880) :542 - 545 . Sci. ,938: 231 - 233 ,discωsion , 233 一 235.
[16J Hung SC , Chen NJ ,比ieh SL , Li H , Ma I-乱,Lo W旺,
ADULT BONE MARRO明儿DERIVED PLURIPOTENTIAL
MESENCHYMAL STEM CELLS GIVE RISE TO SKIN CELLS
AND REGENERATE SKIN TISSUE
DENG Wei Min LI Chang Hong LlAO Lianming* * GE Wei LI Dong YUAN Wen Su
ZHAO Zhi Gang YOU Sheng G∞ DENG Hong Ye and Robert Ch Zhao铮铮
(National Key Laboratory of E.xperimental Hemaω.logy , Institute ofHemaωlogy ,
。tinese Aca.demy of Medi cal Science , Tianjin 300020 )
AßSTRACf Recently stem cell p1asticity has 缸ouse great interests in st臼n cell research for its potential
therapeutic app1ication in degenerative or inherited disea民s. Transp1antation of bone marrow-derived stem cells
in vivo has been shown to give rise to cells of muscl巴 , 1iver,nerve ,endothe1ium ,巳pithelium etc. But there 缸e still
disputes as to ster丑 cell p 1asticity ,as is in the case of ∞ntribution of bone marrow-derived cell to skin cells. Here
we show that cells oo-purified from bone m凹owm巳senchymal stern cells can evidently give riseωskin tissue in
vivo. In the pr岱ent study , we first iso1ated and expanded bone marrow-derived multipotentiar让 mesenchymal
stem cells from BALB/C mice(H-2Kd ,white hair ) ,then co-transp 1anted thern with certain bone marrow cells
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