壳聚糖_海藻酸钠载药微球缓释性能研究.pdfVIP

48 : 2010 12 () 24 12 * 1 2 1 2 1 3 , , , , , ( 1 , 610031;2 , 610065; 3 , 311305) 采用滴球法制备了壳聚糖海藻酸钠载四环素微球, 考察了原料浓度配比四环素投药量 加戊二醛 滴球体积和壳聚糖分子量对微球的影响,并利用紫外分光光度计测试了载药微球在 PBS 溶液中1h5h1d2d5d 4 10d 时的药物释放结果表明,以8.5 10 Da 壳聚糖为原料壳聚糖与海藻酸钠的浓度比为1.21未 加戊二醛 并用大针管滴定的实验组拥有比较理想的缓释性能和良好的生物相容性 Drugreleasing Perfor ance of ChitosanSodiu Alginate Carrying T etracycline Microsphere 1 2 1 2 1 ZHANG Linlin , TU Jianglei , XU Jing , CHENG Liping , ZHANG Zhibin , CHEN Shilong3 ( 1 College of Life Science and Engineering,Southwest Jiaotong University, Chengdu 610031;2 College of Materials Science and Engineering, Sichuan University, Chengdu 610065;3 Zhejiang Lingzhi Fine Che icals Co pany Li ited, Hangzhou 311305) Abstract The chitosansodiu alginate carrying tetracycline icrosphere is anufactured by using icrosphere titration, the effects to the icrosphere are studied by changing stuff concentration rate, carrying edicine dose, titra tion icrosphere size,chitosan olecular weight and considering whether adding the glutaraldehyde. The drugrelea sing perfor ances of icrosphere at 1h,5h, 1d,2d, 5d, 10d are explored with UV spectrophoto eter. The results show 4 that, when the raw aterial is 8. 5 10 Da chitosan, the rate of chitosan and alginate concentration rate is 1.21, and without glutaraldehyde, the experi ent group has the satisfy