控制支原体肺炎：养猪生产重大挑战.pdfVIP

Mycoplasma hyopneumonia Control: An important challenge in pig production 控制支原体肺炎：养猪生产的重大挑战 Dr. Raul Berro Global Director Global Swine Business Unit Mycoplasma– The Disease 支原体引起的疾病 Mycoplasma hyopneumoniae Mycoplasma hyopneumoniae • One of the primary pathogens causing Porcine Respiratory Disease Complex (PRDC)引起猪呼吸道综 合症的首要病原体之一 • Affects as many as 99% of US Asian herds美国和亚 洲99%的猪群受此影响 • There are interaction between Mhyo and secondary bacterial infections支原体与继发性细菌感染有协同作用 (eg.Pasteurella multocida多杀巴氏德菌,Actinobacillus pleuropneumoniae 胸膜肺炎放线杆菌, Streptococcus suis猪链球菌, Haemophilus parasuis副 猪嗜血杆菌): – increase severity of pneumonia and Clinical sign增加肺炎的严 重性及临床症状 R Berro 9/17/2010 2 The Disease The Disease:M. hyopneumoniae M. hyopneumoniae 支原体肺炎 • Clinical sign: Cough, High morbidity and low mortality, Uneven groups of pigs临床症状：咳嗽、高发病率和低 死亡率，猪体型不一 • The lesion of M. hyo increase 1 %, is decrease ADG by 0.4 – 0.9%支原体造成的损伤每增加1% ，平均每日增重 将下降0.4 – 0.9% (Baekboet al., IPVS 2002) • May need extra to reach market weight要达到上市重量 则必须延长饲养天数 – Decrease ADG平均每日增重下降 – Poor FCR 低的饲料转化率 R Berro 9/17/2010 3 Pathogenesis of Mycoplasmosis / Enzootic Pneumonia 致病机理 M. hyo binds to cilia粘附纤毛 Paralyzing, tangling, splitting, breaking cilia破坏纤毛功能 Colonization oftrachea and bronchi定殖气管和支气管 Reducing normal function of mucociliary apparatus降低粘膜纤毛功能 Colonization of airways by bacteria细菌定殖 Enz