皖南地区225例无精子症及严重少精子症患者的细胞遗传学分析.pdfVIP

. 10. 皖南医学院学报(J of Wannan Medical College) 2012 ;31 (I) ·基础医学· 文章编号:1002 -0217(2012)01 -0010 -03 皖南地区 225 例无精子症及严重少精子症患者的细胞遗传学分析 厉荣玉1 ，汤兴丽1 ，董群1 ，陈京1 ，陈其御2 (皖南医学院 1.微生物学与免疫学教研室;2. 优生优育研究所，安徽 芜湖 241∞2) Cytogenetic causation of azoospermia and Conclusion: The findings suggest that chromosomal abnormalities are causative factors of a四ospermia and severe oligospermia ,therefore ,genetic severe oligospermia in 225 patien但 from testing should be ofIered to the men with 田:oospermia and severe oligo- south Anhui areas U Rong-川， TANG Xing-li ,DONG Qun , CHEN Jing , [Key words] 田∞spennia; 阳ere oligospermia; chromosome karyotype CHEN Qi-yu {摘要}目的:研究无精子症及严重少精子症患者与染色 体异常之间的关系。方法:对225 例无精子症及严重少精子 Department of Medical Microbiology and Immunology , Wannan Medical 症患者抽取外周血进行淋巴细胞培养、常规G 显带、核型分 College ,Wuhu 241002 ,China 析。结果:共检出染色体异常核型 64 例，异常率 28.441毛。 其中性染色体异常 39 例(包括 2 例性反转) ，占异常率的 [Abstract] Objective: To investigate the relationship between chromo- some abnormality disorders and 皿:oospermia and severe oligospermia. ω.94%;常染色体结构异常4 例，占异常率6.25% ;染色体 Meth咀命: Peripheral blood samplès were obtained from 225 men with 多态性变异21 例，占异常率32.81 1岛。结论:染色体异常是 皿。ospermia and severe oligospermia and karyotyped on the peripheral 导致无精子症及严重少精子症的重要因素之一，对无精子症 blood lymphocytes by Giemsa banding. Results: Sixty-four abnormal chro- 及严重少精子症患者行染色体检查是十分必要的。 mosomal karyotypes we陀 detected .in 225 patients ( 28. 44% ) , in which I 关键词]无精子症;严重少精子症;染色体核型 盹x chromos