磁共振波谱MEGA-PRESS序列检测帕金森病纹状体γ-氨基丁酸的研究.pdfVIP

实用放射学杂志 2016 年 11 月第 32 卷第 11 期 J Pract Radiol ,Nov. 2016. Vo l. 32 , No.11 • 1655 • 磁共振波谱 MEGA-PRESS 序列检测 帕金森病纹状体 γ-氨基丁酸的研究 任延德l-2 ，龙莉拎2 ，李向荣Z ，秦宇虹Z ，李春燕2 ，戴祷2 ，蒋牧良2 ，叶伟2 (1广西医科大学第一附属医院放射科，广西 南宁 530021;2 青岛大学附属医院放射科) 摘要:目的 探讨 MEGA-PRESS 波谱编稳序列综合LCModel 软件检测帕金森病(PD)J患者双侧纹状体y-氨基丁酸(GABA)浓 度的价值。方法 选取符合诊断标准的 45 例 PD患者和 47 例正常对照组作为研究对象，均行 MEGA-PRESS 波谱编翁序列扫描， 获取 GABA/Cr 值;再应用 LCModel 软件获取 GABA 浓度.结果 (1)与对照组相比，PD 组双侧纹状体GABA 平均浓度升高，差 异有统计学意义(P=O. 045) ;GABA/Cr 值均值升高，但无统计学意义(P=0.183). (2)PD 患者症状严重侧的同。~J 、对侧纹状体 GABAlCr 值及 GABA 浓度比较，无显著位差异(PO. 05). (3) PD 组双侧纹状体 GABA 浓度均值与临床病程、统一帕金森病评 定量表(UPDRS)评分无显著相关性(r=O. 108, 0.031 ;P = O. 438 , 0. 823). 结论 MEGA-PRESS 序列结合 LCModel 软件可以较准 确、客观检测 PD 患者纹状体 GABA 浓度. 关锺询:磁共振波谱;帕金森病;纹状体;γ-氨基丁酸 ∞.:10. 3969/ j. issn.1002-167 1. 2016.1 1. 002 中图分类号:R445.2;R742 文献标志码:A 文章编号:1002一1 671(2016)11-1655一04 Study of detecting y-aminobutyric acid concentration in striatum in Parkison s disease with magnetic resonance spectroscopy MEGA-PRESS sequence REN Yande , LONG Liling , LI Xiangrong , QIN Yuhong ,LI Chunyαn ,DAI Yi ,JIANG Muliang ,YE Wei (Department of Radiology , the First 战ffiliated Hospital of Guangxi Medical Unit吃叨叨， Nanning 530021 ,China) Abstract:Objective To investigate the value of MEGA-PRESS spectroscopy editing sequence combined with LCModel software in the detection of y-aminobutyric acid (GABA) concentrationin in bilateral striatum of patients with Parkison s disease (PD) . Meth- 叫s Forty-five patients met PD diagnostic criteria and 47 normal controls were enrolled in this study. MEGA-PRESS spectroscopy was performed to detect GABA/Cr ratios , and followed by using LCModel software to obtain GABA concentrations. Resulls (1) Compared with the control group , the average o