自体骨髓干细胞移植治疗下肢严重缺血的临床研究.pdfVIP

医学影像学杂志 2010 年第 20 楼第 8 期 Lr.1~d !tnll.Sing yol. 20 ~o. _8 2010 自体骨髓干细胞移植治疗下肢严重缺血的临床研究 虞希祥，来因底，都伟远 (温州院学院附属第三医院介入科浙江瑞安 325200) E摘 要】 目的t 探讨自体骨髓干细胞移植治疗下肢严:1:缺血的临床效果。方法t 对 30 例下肢严重缺血患者，从德锋处 抽取自体骨髓血，分离出单个核细胞，再制成细胞悬液.通过股动脉插管，在球囊阪断动脉血流的情况下将于细胞悬液 垃射到缺血的下肢动脉。编果:Iitt肢疼痛、怜感及静息痛消失 17 例，自 56.7% ，减轻 12 例，占 40.0% ，;;尼变化 1 例，占 3.3%. 间歇性眩行的行走距离延长 100 米的 21 例，占 70.0% ，延妖 50 米的 9 例，占 30.0%. 足趾和(或)足部溃揭 3 例，完全修复 l 例，足部截肢2 例。 27 例足部皮肤颜色均有不同程度恢复. ABI O. 5-0. 6 的 15 例，占 50.0% ;ABI O. 6- O. 7 的 11 例，占 36.7% ,ABI O. 7~0. 8 的 4 例，占 13.3%. 手术并发疲3 例.，5 10.0% ，其中，发热 2 例，占 6.7% ，穿刺点 血肿 l 例，占 3.3% 。结论:自体骨髓子细胞移植是治疗下脏严重缺血的一种简单、黄金、有效手段. 【关键词 自体骨髓干细胞;移植$下肢缺血性疾病 中圄分自障碍 :R543jR815 文，院编哥:1006…901 1( 2010)08-1165一03 文献标i只码 :A Autologous bone man唱w stem cell transplantation in the treatment of severe lower 11mb Iscbemia in clinical study YU Xi-xiang , ZHUGu伊qing. HAO Wei-yuan The Interventional Department. The Third Affiliated Hosþital of WenzhQu Medical College , Zhejiang 325200 , P. R. China (Abstract] ObJective: To investigate the autologous bone marrow stem cell transplantation in the treatment of severe low- er limb ischemia in the clinical effects of. Metbods: 30 cases of severe lower limb ischemia patient嚣. taken from the ilíac of autologous bone marrow bl∞d and isolated mononuclear cells , and then made into cell suspension. Intubation through the femoral artery , balloon occlusion in the case of arterial blood stem cells will be injected into the suspension of the lower ex:幡 tremity arterial ischemia. Results: Limb pain. cold feeling and the disappearance of rest pain in 17 ca恍如 accounting for 56. 7% , 12 cases to reduce. accounting for 40.0% , no change in 1 case. accounting for 3.3%. Intermittent claudication walking distance of 100 meters to e嚣tend the 21 cases. accounting for 70.0%; the extens