阿霉素海藻酸钠微球栓塞对兔VX2肝移植瘤生长及转移影响的实验研究.pdfVIP

• 1108 • 中医医学影像技术 2007 年第 23 卷第 8 期 Chin J Med Imasing Technol.2007. VoJ 23. No R Effeds on growtb and metastasis in rabbit bepatic VX2 carcinoma after transcatheter arterial chemoembolization using Alginate microspberes帽Adriamycin : an experimental study XU Kai-yuo.n) .ZοU Ying-Iwa) ,Q I Xio.t-rongZ ,H()NG Hong 3 (1. Depart~何t of I Iterwntional atld Va5cular Surgery • First H ospital of Pekitlg University, Beijing 10003,I.China 1 2, Schoolof Pharmaceutìca.l Scie町ts. Pekillg Uniwlsity. Beijing 100083 . China; 3. Beiji 1/g Shf!. ttgyi_vao Technolog_v Developme 1ll Corporatio11 f.td , Reiji11g 100088 . China) [Abstract] Obj edlve To evaluale the anlitumor eHect oC transcatheter arterial chemoembolizalion (TACE) with alginate microspl吨re-adriamycin in experime1ltally induced liver tumor, Met以Ids Thrity New Zealand white rabbits were randomly divided imo Jive groups and VX2 carcinoma was grown in lhe left lobes of the livers. TACE was performed with normal 钮 line (Group A) . alginate microsphere (Group B) . algìnate mícrosphere adriamycin (Grollp C) , Lipiodol {Grollp [纱， and Li- piodol-ac:lriamycin (Group E) , Three weeks later , the animals were killed and pathologic parameters were calculated on t he basis of findings. Effects on imrahepatic and distal metastasis in all group8 were examinat~.cl. RfSuJts Alginate microsphere- adr ,amycin Sllppress t he growth 01 tumor and have a high level 01 necrosis. Jn the groups 01 using Alginate microspheres. there were less intrahepatic and distal metastasis comparing with t he others. But no dilference can be seen between Group R 刷、d Group C. High level 01 positive cel1s in TUNJ毛J， (H. 3% 土3. 65 %) were obse ,ved in ( ;ro