聚己酸内酯及其在医药领域的应用.pdf

J Biomed Eng 2003; 20( 4) 746749 张　娜　综述　　郭圣荣　审校 ( 上海交通大学 药学院, 上海　200030) , , , , , ; , Studies on a Kind of New Biodegradable MaterialPolycaprolactone and Developments in Medical Area Zhang Na Guo Shengrong (S ch ool of Phar macy , S hang hai J i aot ong Univ er si ty , Shang hai 200030) AbstractNowdays, there are more and more researches on characters and applications of polycaprolactone ( PCL) . T his paper review s the researches of polycaprolactone, incl ding its synt hesis, physical and chemical , , , . properties biodegradation absorption properties and its applicat ions in clinical se and dr g delivery systems PCL can be from open ring polymerizaion. It is a kind of semi-crystalline polymer, and has good flexbiligy. The degradation reaction of PCL is hydrolysis. PCL is not c m lated in the body , and can be totally excret ed. It can be sed as s t re, material for fixation of bone fract re, vect or of dr g, etc. PCL is widely sed in medical area be- , , . ca se of its safety low toxicit y bidegradability Key wordsPolycaprolact one(PCL) BiodegradationClinical seDr g delivery syst em , , , ( poly( - PCL 140 150 , ) , ) , caprolactone PCL PCL , , PCL : ; ; 12 , ; , 1, 6-; PCL 2