薏苡仁酯提取工艺优化与其滴丸制备.docVIP

薏苡仁酯提取工艺优化及其滴丸的制备 　　[摘要] 目的 对薏苡仁酯提取工艺进行优化，建立薏苡仁酯滴丸制备方法。 方法 以乙酸乙酯作为溶剂，以浸提次数、浸提时间、溶剂用量作为影响因素，薏苡仁酯的得率作为考察指标，采用正交试验优化提取工艺；采用滴制法制备滴丸，以聚乙二醇-6000（PEG-6000）作为基质，液体石蜡作为冷却剂，选择适当的药物基质比、药料温度、冷却温度、滴速及滴距考察滴丸的制备方法，并利用正交试验验证制备方法。 结果 薏苡仁酯的最佳提取工艺为浸提次数2次，浸提时间16 h，溶剂用量10倍，薏苡仁酯得率4.35%；滴丸制备验证结果为滴距5 cm，滴速30滴/min，药物基质比1∶3，药料温度80℃，冷却温度5℃时，滴丸的圆整度、硬度、粘连、拖尾、光泽度等外观指标均较理想，滴丸重量差异符合滴丸质量要求。 结论 薏苡仁酯提取工艺简便，滴丸制备方法操作可行 [关键词] 薏苡仁酯；提取工艺；滴丸 [中图分类号] R914.2 [文献标识码] A [文章编号] 1674-4721（2016）10（c）-0029-04 [Abstract] Objective To optimize the extraction process of coixendide and to establish coixendide drop pill preparation method. Methods The ethyl acetate was chosen as solvent， the number of times， extraction time and solvent usage were considered as the influence factors， and the coixenolide yield was as the index of evaluation， and the extraction process was optimized by orthogonal test. The PEG-6000 as the matrix and liquid paraffin as the coolant for preparing drop pill with the appropriate drug matrix ratio， spices temperature， cooling temperature dropping speed and dropping distance.Results The best extraction process of coixenolide was as follows： Extraction 2 times with 16 hours and 10 times amount of solvent each time and the coixenolide yield was 4.35%. The validation results showed that when the dropping distance was 5 cm， dropping speed was 30 drops every minute， drug matrix ratio was 1∶3， spices temperature was 80℃ and cooling temperature was 5℃， ideal drop pill was produced with appropriate roundness， hardness， adhesion less， tailing less and gloss well. Conclusion The coixendide extraction process is simple and drop pill is feasible preparation . [Key words] Coixendide； Extraction process； Drop pill 薏苡仁是禾本科植物薏苡Coix lacryma-jobi L.var.mayuen（Roman.）Stapf的干燥成熟种仁，其味甘、淡，性凉，具有利水渗湿、健脾止泻、除痹、排脓、解毒散结的功效。薏苡仁在中国本草学《神农本草经》等中均列为延年益寿的上等药，日本一直视薏苡仁为一种珍贵的滋补品，在欧洲称之为“生命健康之禾”，在中国民间常作为药食两用品种。传统上薏苡仁常用于水肿、脚气、小便不利、脾虚泄泻、湿痹拘挛、肺痈、肠痈、赘疣、癌肿等症。现代医学认为，薏苡仁具有增强免疫[1]、镇痛抗炎[2]、抗肿瘤[3]、降血糖[4]、抗辐射[5]等药理作用，薏苡仁含丰富的蛋白质、脂肪