高尿酸血症性肾病的发病机制与药物治疗.pdfVIP

Journal of Physiology Studies 生理学研究, 2016, 4(1), 1-9 Published Online February 2016 in Hans. /journal/jps /10.12677/jps.2016.41001 Pathogenesis and Treatment of Chronic Hyperuricemic Nephropathy 1 2 1 1* Xiaolu Meng , Xin Li , Baoxue Yang , Hong Zhou 1 State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 2 The Affiliated Hospital of Qingdao University, Qingdao Shandong th th th Received: Mar. 9 , 2016; accepted: Mar. 27 , 2016; published: Mar. 30 , 2016 Copyright © 2016 by authors and Hans Publishers Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). /licenses/by/4.0/ Abstract Large numbers of epidemiological and clinical studies in recent years have accumulated that hyperuricemia may be strongly linked with many metabolic diseases, including hypertension, cardiac-cerebral vascular disease, diabetes and metabolic syndrome. It has been regarded as a severe disease threatening human health and an independent risk factor in the progression of kidney diseases as well. As the end product of purine metabolism, uric acid can induce renal injury through multiple mechanisms, such as inflammation, renal fibrosis, oxidative stress and epitheli- al-to-mesenchymal transition. To further study the pathogenesis of hyperuricemia nephropathy and potential targets involved, we mainly discuss the physiopathologic mechanism and medical treatment of hyperuricemia in this review.