脊髓损伤机制及骨髓间充质干细胞移植治疗机制的研究.pdfVIP

2016 年 12 月 生物骨科材料与临床研究 .68. ÜRTHOPAEDIC BIOMECHANICS MATERIALS AND C LlNICAL SruDY 第 13 卷第6 期 doi: 10.3969/j .issn.1672-5972 .2016.06.18 文章编号 swgk20 16-06-00 150 睡前噩噩黯缸噩 脊髓损伤机制及骨髓间充质干细胞移植治疗机制的研究* 杨新明胡长波成是豆 [摘要]脊髓损伤 CSCI)机制分为初级阶段和次级阶段。初级阶段是不可逆转的原发机械性损伤过程，次级阶段 是可逆且可控制的继发性损伤引发的炎症反应、脂质过氧化反应、细胞凋亡等生物化学反应过程:骨髓间充质 干细胞移植可以对 SCI 进行干预治疗，其治疗机制主要为减轻 SCI 区炎症反应，抑制氧化应激，分泌神经营养 因子，分化成神经元和胶质细胞，促进轴突再生及髓稍重新形成。 SCI 机制的发生是一系列多元化生物化学反 应，骨髓间充质干细胞移植对其治疗具有良好的应用前景，其机制亦是多因素协同作用的结果，但具体机制仍 需要进一步深入研究。 [关键词]脊髓损伤:损伤机制:骨髓间充质干细胞:治疗机制 [中图分类号1 R744 [文献标识码1 B Spinal cord injury mechanism and mechanism of bone marrow mesenchymal stem cell transplantation therapy be- tween research progress Yang Xinming , Hu Changbo, Cheng }每oli. Department ofOrthopedic, the First Aflíliated Hospital ofHeßei North University, Zhangjiakou Hebei, 075000, China IAbstractl Mechanism is divided into stages ofprimary and secondary spinal cord i叮ury. Primary stage is an irreversible process ofprimary mechanical damage , the secondary stage is reversible and controllable secondary i町ury caused by in- f1 ammation , lipid peroxidation , apoptosis and other biochemical reaction process; Between bone maπow mesenchymal stem cell transplantation for spinal cord i町ury intervention treatment , its treatment mechanism is mainly to reduce area inf1 ammation of spinal cord i时ury， inhibiting oxidative strωs， secrete neurotrophic factors , differentiate into ne町ons