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8 4 Vol. 8 No. 4
2017 4 Journal of Food Safety and Quality Apr. , 2017
周微芳, 范卓妍, 姜松松, 韩诗雯, 车会莲*
(, , 100083)
摘 要: ,
, ;
, ,
,
关键词: ; ;
Advances in animal and cell models for the evaluation of food allergy
*
ZHOU Wei-Fang, FAN Zhuo-Yan, JIANG Song-Song, HAN Shi-Wen, CHE Hui-Lian
(Beijing Advanced Innovation Center for Food Nutrition and Human Health , College of Food Science and
Nutritional Engineering , China Agricultural University, Beijing 100083, China)
ABSTRACT: Animal and cell models are one of the most commonly used methods in evaluating the sensitivity of
food allergens. Murine models have advantages of a short breeding cycle and genetic maneuverability characteristics,
but also have shortcomings in differences of genetic background and ethical. In vitro , the cell models can offset the
deficiency of animal models which reflect the changes of the allergic reaction from the general to the detail. Others
methods such as gastrointestinal digestion and thermal stability test are also used in evaluating the food allergy,
however, all of these methods have certain limitations. This review summarized the advantages and disadvantages of
animal and cell models in the current study, and their relationship with other experimental methods, and analyzed
their effects in the evaluation of food allergens.
KEY WORDS: food allergy
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