3-甲基-4-氨基-5-[二-(4-氟苯基)]甲硫基-1,2,4-三氮唑席夫碱的微波合成及表征.pdfVIP

2010 年第 30 卷 有机化学 飞rol. 30, 2010 第 10 期， 1555-1558 Chinese Joumal of Organic Chemistry No. 10, 1555-1558 ·研究简报· 3-甲基-4-氨基-5-[二-(4-氟苯基)]甲硫基-1 ， 2，4-三氮咄席夫碱的 微波合成及表征 学清寒* 崔浩 (回南民族大学化学与环境保护工程学院 成都 610041) 摘要微披辐射f，工氨慕硫llHI与乙股反应制得 3- 甲慕-4-辄藕-1 ，2，4-气氮略-5-硫嗣(1)，在无水乙醇中以三乙腋作为反 应的缚酸剂， 1 与[二-(4-氟苯基)]甲基氯经微波辐射制得中间体 3- 甲盛斗，氟草帽5-[工-(4-氟苯基))甲硫基斗，2，4-三氯哇。)， 然扁中间体2 与芳沓陪经缩什反应制得了 10 个 Schiff 碱3a~3J. 合成的 10 个目标化合物通过熔点测定和质谐、红外 光谱、核随共振氧谱分析、元素分析对其结构进行确记 关髓词 1 ，2，4-王三组咄 Schiff 碱;二-(4-氟苯基)甲占主氯;有机合成;做被辐射 Microwave-Assisted Synthesis and Characterization of 3-Methyl-4- amino-5-[b←(4蛐fluorophenyl)-methyl]-thio唰 1 ,2,4-triazole Schiff base Li, Qinghan* Cui, Hao (College ofChemistry and Environmental Protectíon Engineeríng, Southwest Uníversjψ， for Natíonalitíes , Chengdu 610041) Abstract Under microwave irradiation conditions, ten Schiff bases 3a_3j have been synthesized. Firstly thiocarbazide was reacted with acetic acid to prepare 4， 5-dihydro-3-methyl-4-amino斗，2，4-triazole-ιthione (1). Then compounds 1 reacted with [bi-(4-fluorophenyl)]methyl chloride in the presence of triethylamine and ethanol ωfonn the key intermediate 2. The target compounds 3a-3j were synthesized by the conden- sation between substituted benzaldehyde and the intermediates 2 in acetic acid medium. The structures of target compounds have been confirmed by IR, l H NMR , MS techniques and elemental analysis. Keywords 1,2,4-triazole Schiff base; [bi-(4-fluorophenyl)]methyl chloride; organic synthesis; microwave irradiation 三睡环樊杂坏化合物具有广泛的生物活性.它们町 和生物活性的研究一直是化学工作者关性和研究的热 用作杀真商剂、抑翩剂和植物生长调节荆(1- 坷，如