Guanosine的酰化与酯解——均匀设计用作有机合成中的新颖计量化学技术(英文).pdfVIP

　　第20卷　第4 期　 吉首大学学报(自然科学版) Vol.20　No.4　　 　　1999 年12 月 Journal of Jishou University (Natural Science Edition) Dec..1999　　 Article ID:1007-2985(1999)04-0010-05 Acylation and Acylolysis of Guanosine ———Unifor (Ho ogeneous)Design Used as A Novel Che o etric Technique in Organic Synthesis LI Zhi-liang, SHENG Qi-ting, YANG Nan-lin, XIAO Min, LIANG Ben-xi, AN De-lie, QIAN Feng,YUAN Xiao-yan (Dept.of Che istry Che .Eng., Institute of Che o otrics and Phar acy(ICF), Hunan University, Changsha 410082, Hunan, China) Abstract:Unifor design (UD)or called ho ogeneons design (HD)can be used as a novel che o et- ric, called syntho etrics or syntheto etric tool and applied to experi ental design and opti ization of or- 2 ganic synthesis.N -acetylauanise (NAG)and tetracety1-β-D-rivofuranose (TAR)were prepared fro guanosine through acylation and acylolysis, respectively.Ho ogeneous design and stepwise regression have been e ployed to search the opti al conditions of the reacion.The syntheticyields of NAG and TAR were increase to 90.3%and 69.8%fro 72.2%and 35.6%, respectively. Key words:unifor design, ho ogenous design, stepwise regression, che o etrics, syntheto etrics, syn- tho etrics, acylation and acylolyis of guanosine CLC number:O626;O621.3　　　　　Doument Code:A In organic synthesis and phar aceutical industry, the proble s such as design of synthetic pathways and opti ization of reaction condition ay frequently be encountered[1～4] .Orthogonal design (OD)is a [1] widely applicable experi ental designing ethod for ultiple