EGFR、Her-2、HIF-1α、p53对进展期食管鳞癌新辅助化疗疗效的预测价值.pdf

现代肿瘤医学 2016 年 10 月 第 24 卷第 20 期 MODERN ONCOLOGY ，Oct . 2016, VOL . 24, NO . 20 • 3209 • EGFR、 Her -2 、 HIF - l a 、P53对进展期食管鱗癌新辅助化疗疗效的预测 价值 丁兆军1 ，孟令新1 ，周晓明1 ，成之福1 ，王刚平1 ，张 红 1 ，薛英杰2 The application of EGFR,Her - 2 ,H IF - 1 a lp h a ,p 5 3 for neoadjuvant chem otherapy cur­ ative effect prediction in advanced esophageal squam ous carcinom a Ding Zhaojun 1 ,M eng Lingxin 1 ,Zhou Xiaom ing 1, Cheng Z h ifu 1 ,W ang Gangping 1, Zhang Hong 1 , Xue Y ingjie 2 1 Oncological Department ,Rizhao Peopled Hospital y Shandong Rizhao 216S26, China^Information Engineering College o f Medicine ^ Ji- ning Medical University Rizhao Campus y Shandong Rizhao 216^26 y China. 【Abstract 】 Objective : To investigate the predictive value of neoadjuvant chemotherapy ( NAC) curative effect of E G F R ,H er-2 ,H IF -1 alpha and p53 in advanced esophageal squamous cell carcinoma (ESC C ). Methods ：Retro­ spective analysis was studied for 94 cases advanced esophageal squamous cell carcinomas ( IH period) from January 2011 to January 2015. These patients were treated by neoadjuvant chemotherapy (paclitaxel plus cisplatin regimen). Expression of EGFR, Her - 2 , HIF - 1 alpha and p53 was detected by immunohistochemical method. RECIST1. 1 standard combined with pathological histology was applied to evaluate chemotherapy ( CT) curative effect. Logistic multifactor regression analysis was applied to investigate the relationship of these index. Results ：The total effective rate was 56. 38% (5 3 /9 4 ) ,all were partial response. Stable disease accounted for 4 1 .49% (3 9 /9 4 ) , disease progres­ sion was 2. 13% (