局部进展期乳腺癌新辅助化疗前后生物标志物表达变化与疗效的相关性.pdf

医学 2016年 01月 第 24卷第 01期 MODERNONCOLOGY．Jan．2016．VOk24．NO．01 ·59· 局部进展期乳腺癌新辅助化疗前后生物标志物表达变化与疗效的相关性 石 阳r，李 琦 ，李 蓉 ，田 聆 Correlationofbiomarkerexpressionandtherapeuticefficiencyinlocallyadvancedbreast cancerafterneoadjuvantchemotherapy Shirang ，LiQi，LiRong。，TianLing ExperimentalResearchCenter＆ComprehensiveCancerCenter，ShanghaiGeneralHospita1．ShanghaiJiaotongUniversitySchoolofMedi— cine，Shanghai200080，China；。DepartmentofOncology；DepartmentofBreastSurgery，HuangpuCentralHospital，Shanghai200002， China． A【bstract】 Objective：Toevaluatetherelationoftherapeuticefficiencyoflocallyadvancedbreastcancerafterneo— adjuvantchemotherapywithrelatedbiomarkers．Methods：TheexpressionofER，PR，HER一2，p53andKi一67in clinicaltissuesamplesfrom 102patientswithlocallyadvancedbreastcancerweredetectedbyimmunohistochemistry， andanalyzethecorrelationbetweenthebiomarkerexpressionandthetherapeuticefficiency．Results：Theefficiencyof theneoadjuvantchemotherapyinERnegativegroup(50．0％)，PRnegativegroup(49．1％)，Ki一67overexpression group(51．4％)weresignificantlyhigherthna thatinERpositivergoup(26．0％)，PRpositivegroup(25．5％)， Ki一67lowexpressiongroup(9．4％)(P0．05)．Logisticrergessionanalysisshowedthattheexpressionlevelof ER，Ki一67wasanindependentfactorforthechemotherapyefficacy．Breastcancerpatientswith Luminaltypehave higeroverallsurvivalthannon—Luminaltype(P0．05)．Conclusion：ER，Ki一67andmolecularsubtypescanpre— dictthetherapeuticefficiencyofneoadjuvantchemotherapyinlocallyadvancedbreastcancer． K【eywords】locallyadvancedbreastcancer，neoadjuvantchemotherapy，biomarkers，molecularsubtyping，therapeutic efficiency ModemOneology2016，24(01)：0059—0063 【摘要】 目的：探讨局部进展期乳腺癌行新辅助化疗前后相关生物标志物的表达变化情况与化疗疗效的相 关性。方法：采用免疫组化方法检测 102例新辅助化疗前后局部进展期乳腺癌组织中雌激素受体 (ER)、孕激 素受体 (PR)、人类表皮生长因子受体一2(HER一2)、p53和增殖细胞核抗原 (Kj一67)等表达，分