降钙素原指导下肠梗阻预防性抗生素应用的临床价值.pdfVIP

第 卷第 期 44 5 温 州 医 科 大 学 学 报 Vol.44 No.5 第 卷年 月 第 期 201444 5 Journal of Wenzhou Medical University May.20145 温 州 医 科 大 学 学 报 ·临床经验· 降钙素原指导下肠梗阻预防性抗生素应用的临床价值 李绍堂，蒋飞照，朱恒梁，阮小蛟，郑晓风 （温州医科大学附属第一医院 普外科，浙江 温州 325015） [摘  要] 目的：探讨降钙素原指导下肠梗阻预防性抗生素应用的临床价值。方法：观察80例拟行非手术 治疗的肠梗阻患者预防性抗生素应用的效果。80例患者在入院后第1、第3、第5天等隔日抽血检查降钙素 原及血常规水平，至研究截点。其中40例患者（试验组）在降钙素原正常 （＜0.5 ng/mL）后停用抗生素。 其余40例患者 （对照组）依据传统标准停用抗生素。比较两组患者的治愈时间、感染相关并发症与抗生素 应用天数。结果：两组患者治愈时间和感染并发症差异无统计学意义 （P＞0.05）。两组患者平均用药时间 比较，试验组明显低于对照组，差异有统计学意义 （P＜0.01）。结论：降钙素原指导下肠梗阻预防性抗生 素应用要优于传统标准抗生素应用。 [关键词]  降钙素原；肠梗阻；抗生素；预防性；应用 [中图分类号]  R605  [文献标志码]  B  [文章编号]  1000-2138（2014）05-0367-03 The clinical value of prophylactic antibiotics application under the guidance of procalcitonion in intestinal obstruction LI Shaotang, JIANG Feizhao, ZHU Hengliang, RUAN Xiaojiao, ZHENG Xiaofeng. Department of General Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015 Abstract: Objective: To explore the clinical value of prophylactic antibiotics application under the guid- ance of procalcitonion in intestinal obstruction. Methods: The results of prophylactic antibiotics application were observed and analyzed in 80 cases of non-surgical treatment of intestinal obstruction. Procalcitonion and blood routine were tested in all cases in 1, 3, 5 day after admission such as cut point for research. Forty patients (experimental group) stopped using antibiotics under the normal level of procalcitonion (0.5 ng/mL). The rest of 40 patients (control group) stopped using antibiotics on the basis of traditional standard. Results: There was no significant difference between two groups in cure time