不同制备方法对水溶性药物氢化蓖麻油骨架缓释片影响Δ.PDFVIP

不同制备方法对水溶性药物氢化蓖麻油骨架缓释片的影响Δ ＊ # 王秀丽 ，徐焕焕，党晓芳，马 群 ，陶 欧（北京中医药大学中药学院，北京 100102） 中图分类号 R284.2；R283 文献标志码 A 文章编号 1001-0408（2014）31-2905-03 DOI 10.6039/j.issn. 1001-0408.2014.31.09 摘 要 目的：探索以氢化蓖麻油作为缓释片的骨架时，蜡质骨架片常规制备方法以外的3种不同制备方法对骨架片成型性及水 溶性药物释放的影响。方法：以紫外分光光度法为检测方法，以累积释放度为检测指标，并结合流动性及可压性，考察湿法制粒压 片、干法制粒压片及全粉末压片法对水溶性模型药物维拉帕米和肉苁蓉提取物的氢化蓖麻油骨架缓释片的成型性及药物释放的 影响。结果：采用湿法制粒压片、干法制粒压片、全粉末压片的方法成功制得维拉帕米氢化蓖麻油骨架缓释片和肉苁蓉提取物氢 化蓖麻油骨架缓释片。结论：氢化蓖麻油作为蜡质骨架，可以采用湿法制粒压片、干法制粒压片、全粉末压片的方法进行压片。该 试验结果可为水溶性药物氢化蓖麻油骨架缓释片的研制提供一定的参考。 关键词 氢化蓖麻油；制备方法；缓释片；水溶性药物 Effects of Different Preparation Methods of Hydrogenated Castor Oil Matrix Sustained-release Tablets for Water-soluble Drug WANG Xiu-li ，XU Huan-huan ，DANG Xiao-fang ，MA Qun ，TAO Ou （College of TCM ，Beijing University of TCM ，Beijing 100102，China ） ABSTRACT OBJECTIVE ：To explore the effects of 3 kinds of preparation methods except wax matrix tablet routine preparation method on the moldability of matrix tablet and the release of water-soluble drugs using hydrogenated castor oil as matrix. METH- ODS ：Using accumulative release rate as index ，based on fluxility and compressibility ，UV spectrophotometry was used to investi- gate the effects of wet granulation tabletting ，dry granulation tabletting and power tabletting methods on the moldability of Hydroge- nated castor oil matrix sustained-release tablets for water-soluble model drug as verapamil and Cistanche deserticola extract. RE- SULTS ：Hydrogenated castor oil matrix sustained-release tablets of verapamil and C. deserticola extract were prepared by using wet granulation tabletting ，dry granulation tabletting and power tabletting method in this study. CONCLUSIONS ：Hydrogenated castor oil is used as wax matrix and can be compress into the tablet through wet granulation tabletting ，dry granulation tabletting and pow- er tabletting method. T