丹参注射液对急性脊髓损伤大鼠突触体素和突触素的作用及机制_韦理.pdfVIP

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丹参注射液对急性脊髓损伤大鼠突触体素和突触素的作用及机制_韦理.pdf

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丹参注射液对急性脊髓损伤大鼠突触体素和突触素的作用及机制_韦理

• 1870 • ( ) 2013 6 286 CJTCMP , June 2013, Vol . 28, No. 6 P Effect of Salvia Miltiorrhiza on synaptophysin and synapsin of spinal cord injury in rat and its mechanism 1 2 WEI Li , ZHANG Li 1 2 ( Guangxi University of Chinese Medicine, Nanning 530001, China; Fujian University of Chinese Medicine, Fuzhou 350108, China ) Abstract: Objective: To observe the effect of Salvia Miltiorrhiza on synaptophysin and synapsin of acute spinal cord injury in the gray matter of rats and discuss its mechanism. Methods: 144 male SD rats were made SCI models and randomly divided into three groups including the observation group, control group and SCI group. The observation group was treated with Salvia miltiorrhiza injection. The control group was treated with methylprednisolone. SCI group was treated with nothing. Changes of synaptophysin and synapsin were observed on the ﬁ rst day, the third day, the 7th day and the 14th day after SCI. Results: There was no signiﬁ cant difference on the density of synaptophysin immunoreactivity and synapsin immunoreactivity in the