环境雌激素17β-E2对栉孔扇贝内分泌干扰的作用机制.pdfVIP

Abstract Abstract Endocrine disrupting chemicals (EDCs ) are chemicals that at certain doses, can interfere with the endocrine (or hormone system) in organisms. These disruptions can cause cancerous tumors, birth defects, and other developmental disorders. Any system in the body controlled by hormones, can be derailed by hormone disruptors. Most research on adverse effects of EDCs has focused on impacts to the vertebrates in past years. However, much less is known about the effects of endocrine disruption in the invertebrate phyla which represent ~95% of all animal species, despite the fact that alternation in the sexual development of certain mollusks species by the organotin compounds. Recently, an increasing amount of evidence that is the incidences of intersex (feminization) in many bivalve species had been found in coastal worldwide, implying that EDCs did the adverse impacts on the bivalves in reproduction, population and ecological functions. And so, it is one of key issues to understand the potential mechanism of intersex in bivalves, which is helpful to reduce the ecological risk caused by EDCs and to strength environmental management. Zhikong Scallop Chlamys Farreri is a native bivalves and one of the most important aquaculture species in China coast. The present study analyzed their endogenous hormone variations in Zhikong scallop Chlamys Farreri during a reproductive cycle using UPLC-MS/MS. Synchronized with the gonad development, the T levels exhibited a similar temporal pattern characterized by one peak in spawning stage. While, E2 concentrations increased at the development stage and then decreased sharply before