壳聚糖-海藻酸盐复合物的表征及其吸湿性和崩解性研究.pdfVIP

上海交通大学学报 Vo l. 41 No.10 第 41 串串 10 期 2007 年 10 月 JOURNAL OF SHANGHAI jlAOTONG UNIVERSITY Oct. 2007 文章编号: 1006-2467(2007) 10-1683-04 壳聚糖-海藻酸盐复合物的表征及其 吸湿性和崩解性研究 陆轶业， 刘 黎， 张亚琼， 郭圣荣 (上海交通大学药学院，上海 200240) 摘 要:壳聚糖和海藻政纳在水溶液中能以静电自组苯形成聚电解质复合物.利用红外光谱和元 章分析在征复合物结构，考察复合物的结晶性、吸湿性及压片后的崩解性.结果表明，壳聚糖-海藻 酸盐~合物呈元定型态，其吸湿性明显高于壳聚糖和海藻酸钩本身，特别是在 pH 值为 5.0 条件下 得到的复合物吸湿性较大.崩解性实验在明，主合物具有相当好的崩解性能. 关键词:先聚糖p 海藻政纳;~合物，吸湿性p 崩解性 中图分类号: 0636 文献标识码 A The Characterization , Moisture-absorption Abilities and Disintegration of the Complexes of Chitosan-Alginate LU Yi-ye , LIU Li , ZHANG Ya-qiong , GUO Sheng-roηg (School of Pha口nacy ， Shanghai Jiaotong Univ. , Shanghai 200240 , China) Abstract: Chitosan and alginate can form polyelectrolyte complexes in water via electrostatic interaction. The complexes were characterized by FTIR and element analysis , and their crystallization , moísture-ab- sorption and disintegration were also investigated. The results show that chitosan-alginate complexes pres- ent amorphous state , and their moisture-absorption abilities are better than the original chitosan and algi nate. The complexes have great moisture-absorption abilities when prepared from the solution of pH 5. O. The complexes exhibit excellent disintegratîon effect. Key words: chitosan; alginate; complex; moisture-ahsorption ability; disintegration 海藻酸纳(Sodium alginate , Sa) 是一种天然聚 生物材料、药物控释等领域显示出广阔的应用前景. 近年来的研究多为利用壳聚糖-海藻酸盐复合物制 阴离子化合物，主要存在于褐藻中，其分子链中包含 备新型膜材料、纤维f11. 制备微纳米粒子来包裹细 了 α-1.4 结构 L 型古洛糖隆酸和β1 ， 4 结构 D 型甘