HumanImmunologyandApplicationinMedicine人体免疫及药.ppt

Human Immunology and Application in Medicine 人體免疫與藥物應用 Immunology Self-defense Pathogens: Bacteria Virus Parasites (1)　The Mechanism for How to Defense (2)　How to Strengthen Immune System Edward Jenner and Cowpox Vaccine Edward Jenner,M.D.(British) 1789 將取自擠奶女工痘痂之牛痘病毒(Cowpox Virus)，給一位八歲男孩子接種，使他得到抵抗天花病毒(Smallpox Virus)感染之免疫力 —Active Immunisation. 1900 Germany Chemist Paul Ehrlich and Ab Phytotoxin免疫老鼠後得到之血清 (Antitoxin)具有中和植物毒素的作用 　　　　　　　　　　　　---Antibody Side Chain Theory 1908 Nobel Prize Elie Metchnikoff and Phagocytes 1885 Biologist(Russia) Elie metchnikoff發現以玫瑰刺進Invetebrates體內其周圍會出現Macrophagocytes後來在哺乳動物發現也有此類Cell 1908 shared Nobel Prize with Paul Ehrlich Basic Components of 　　　　　　　　the Immune System Central Nerve System Inhibitors 1. Alcohols Stimulation first, Then Inhibition of CNS Disulfiram(Antabuse) Block Metabolism of EtOH 2. Barbituates Secobarbital Seconal,Red,红中 紅色膠囊 Amobarbital Amital 青發 青色膠囊 Methaqualone Nominox,White白板 白色藥片 To CNS Like Morphine Benzodiazepine Triazolam(Halcion) 小白板 has all of the characteristic benzodiazepine pharmacological actions.It is marked as a sedative-hypnotic drug. 3.CNS depressant Anxiolytic,Sedative, Hypnotic Morphine Extracted From Opium Papaver somniferum Analgestic Heroine Pentazocine Talwin, Sosegone(Taiwan) 30-50mg=10mg of Morphine White Crystalline Powder Estrogen: Development of secondary sex Characteristics in women at Puberty Development of Lipid Other Tissues that contribute To Breast Shape and Function. Fluid Retention in the Breast. Development of Vagina,Uterus. Pigmentation of the nipples. DES: Diethylstilbestrol Same Activity of Estrogen Phytoestrogens: Several Natural Plant Substance That have Gen