Lin28Let-7C-myc调节环及鼻咽癌靶向治疗关系研究进展.PDFVIP

中华临床医师杂志( 电子版)2015 年11 月第9 卷第21 期 Chin J Clinicians(Electronic Edition),November 1,2015,Vol.9,No.21 ²3997 ² ²综述² Lin28/Let-7/C-myc 调节环与鼻咽癌靶向治疗关系 研究进展 饶丽华 【摘要】 近来认为鼻咽癌干细胞的存在是导致放射抵抗最重要的原因。Lin28 是一种原癌基 因，通过选择性阻断Let-7 miRNA 家族成员的加工合成，阻碍miRNA 对原癌基因的抑制作用。同 时又与RNA 解旋酶相互作用，增强基因翻译，并且Let-7 对Lin28 和C-myc 起反馈抑制调节作用。 C-myc 调控DNA 损伤检验点反应，引起鼻咽癌干细胞的放疗耐受性，我们回顾性分析相关文献，探 讨Lin28/Let-7/C-myc 调节环与鼻咽癌干细胞的靶向治疗关系的研究进展。 【关键词】 鼻咽癌； 干细胞； 分子靶向治疗； Lin28/Let-7/C-myc ； 调节环 Progress in the study of relationship between Lin28/Let-7/C-myc feedback loop and radiation tolerance of nasopharyngeal cancer stem cells Rao Lihua. Department of Otolaryngology-Head and Neck Surgery, the Second Hospital of Sanxia University, Yichang 443000, China Email: 819913513@ 【Abstract 】 The existence of nasopharyngeal cancer stem cells are regarded as the most important reason of radiation resistance. As a proto-oncogene, Lin28 selectively block the processing synthesis of the members of Let-7 miRNA family and block the function of miRNA inhibiting proto-oncogenes. At the same time, Lin28 interact with RNA helicase to enhance gene translation. And Let-7 act as feedback regulation on Lin28 and C-myc. C-myc regulates DNA’s checkpoint reaction damage, leads to the radiation resistance of nasopharyngeal carcinoma stem cells, we retrospectively analyzed the relevant literature and evaluated the research progress between Lin28/Let-7/C-myc and targeting therapy of nasopharyngeal carcinoma stem cells. 【Key words 】 Nasopharyngeal cancer; Stem cells; Molecular targeted therapy; Lin28/Let-7/C-myc; Feedback loop  一、鼻咽癌干细胞 之面临发展瓶颈之中。研究表明放射抵抗性是这些 鼻咽癌是