糖尿病患者脑钠肽前体水平与心率变异性的相关性详解.PDFVIP

·146 · doi 10.3969/j.issn. 1673-4254.2015.01.30 J South Med Univ, 2015, 35(1): 146-148 临床研究 糖尿病患者脑钠肽前体水平与心率变异性的相关性糖尿病患者脑钠肽前体水平与心率变异性的相关性 1 2 2 3 4 林 茴 ，陈小欢 ，吴志华 ，张东辉 ，陈晓燕 1 2 3 4 深圳市第四人民医院 功能科，内分泌科，心内科，检验科，广东 深圳 518000 摘要：目的 探讨糖尿病患者脑钠肽前体水平（NT-proBNP ）和心率变异性（HRV）的相关性。方法 对58 例糖尿病患者均进行 HRV 分析与NT-proBNP 测定，按HRV 结果分为HRV 异常组和HRV 正常组，比较两组的时域和频域指标以及NT-proBNP 水平， 并将所有患者的HRV 指标与NT-proBNP 进行相关性分析。结果 HRV 异常组NT-proBNP 水平（320.2±88.3 pg/ml ）与HRV 正 常组（80.4±25.2 pg/ml ）比较，显著增高（P0.01），NT-proBNP 与SDNN、三角指数、低频功率、极低频功率负相关（r=-0.55, P 0.05; r=-0.52, P0.05; r=-0.62, P0.01; r=-0.56 ，P0.05）。结论 糖尿病患者NT-proBNP 水平与HRV 相关，NT-proBNP 升高提 示糖尿病的心脏自主神经病变。 关键词：糖尿病；心率变异性；脑钠肽前体；心脏自主神经病变 Association of pro-B-type natriuretic peptide levels with heart rate variability in diabetic patients 1 2 2 3 4 LIN Hui , CHEN Xiaohuan , WU Zhihua , ZHANG Donghui , CHEN Xiaoyan 1Department of Function, 2Department of Endocrinology, 3Department of Cardiology, 4Department of Clinical Laboratory, Fourth People ’s Hospital of Shenzhen, Shenzhen 518000, China Abstract: Objective To investigate the correlation between pro-B-type natriuretic peptide (NT-proBNP) and heart rate variability (HRV) in patients with diabetes. Methods HRV and NT-proBNP levels were assessed in 58 patients with diabetes. The time domain and frequency domain indices and the level of NT-proBNP were compared between patients with normal and abnormal HRV, and the correlation of HRV index and NT-proBNP was analyzed. Results The NT-proBNP level was significantly higher in patients with abnormal HRV than in those with normal HRV (320.2 ± 88.3 vs 80.4 ± 25.2 pg/ml, P0.01). The level of NT-proBNP was negatively correlated with SDNN (r=-0.55, P0.05), triangle index (r=-0.52, P0.05), LF (r=-0.6