癫痫诊断治疗进展_培训课件.pptVIP

传统抗癫痫药对新型抗癫痫药血清剂量的影响 *No effects on gabapentin or levetiracetam. Adapted from French JA, et al. Epilepsia. 2000;41(suppl 8):S30-S36. 新型抗癫痫药对传统抗癫痫药血清剂量的影响 Adapted from French JA, et al. Epilepsia. 2000;41(suppl 8):S30-S36. 根据AED药代动力学特征合理搭配 AED added Existing AED PB PHT GBP CBZ CZP VPA LTG TPM LEV PB AI ↓↓/↑↑PHT 0 ↓↓CBZ ↓CZP ↓↓VPA ↓↓LTG ↓↓TPM 0 PHT ↑↑PB AI 0 ↓↓CBZ ↓CZP ↓↓VPA ↓↓LTG ↓↓TPM 0 GBP 0 0 - 0 0 0 0 0 0 CBZ 0 ↓↓/↑↑PHT 0 AI ↓CZP ↓↓VPA ↓↓LTG ↓↓TPM 0 CZP 0 ↓/↑PHT 0 0 - 0 0 0 0 VPA ↑↑PB ↓↓/↑↑PHT 0 ↑↑CBZ-E 0 - ↑↑LTG 0 0 LTG 0 0 0 ↑CBZ-E 0 0 AI ? 0 TPM 0 ↑↑PHT 0 0 0 ↓↓VPA ? - 0 LEV 0 0 0 0 0