18-肿瘤免疫研课程班2016.pptx

肿瘤免疫 Tumor Immunity 肿瘤抗原 机体抗肿瘤的免疫机制 肿瘤的免疫逃逸机制 肿瘤的免疫治疗 Model of sequential genetic alterations leading to metastatic colon cancer. Each of the stages indicated at the bottom is morphologically distinct, allowing researchers to determine the sequence of genetic alterations. 多次打击模型(Multihit Model) 一、肿瘤特异性抗原 二、肿瘤相关性抗原 肿瘤抗原 (Tumor Antigens) 化学和物理致癌因素诱发的肿瘤抗原 病毒诱发的肿瘤抗原 癌基因和突变型抑癌基因表达的肿瘤抗原 正常静止基因表达的肿瘤抗原 一、肿瘤特异性抗原 Mice were induced to produce tumors by the injection of a chemical carcinogen (methyl-cholanthrene). Tumor cells from these mice were then injected subcutaneously into genetically