W7-9生存析.ppt

Survival Analysis;Chapter 1;Time-to-event data;Survival data;Special features of survival data;Feature of survival data;Example: BSI;Example: BSI;Epidemiology study;Example: Lung cancer;Example: Lung cancer;Genetic study;Example: STAR*D;Example: STAR*D;Example: STAR*D;Clinical Trials;Design a survival study;Distribution Specification;Hazard function;Connections;Moment parameters;Distribution percentiles;Censoring mechanism;Right censoring;Three types of censoring ;Independent censoring;Independent censoring;Non-informative censoring;Other censoring pattern;Software;Chapter 2;Overview of the chapter;Estimation;Estimation of distribution function when complete data are available;Using Empirical Estimator;KM Estimation;Property of KM estimator;Greenwood formula for variance;Example: Lung Cancer;R function and sample code (taken from help documents for survfit);Estimator of Cumulative Hazard(Nelson-Aalen Estimator);Flaming-Harrington (FH) Estimator;Comparison;FH is above KM;Critical assumption: Independent censoring;Parametric method;Exponential distribution;Weibull distribution;Pareto distribution;Log-normal distribution;Log-logistic distribution;Gamma distribution;Bathtub-hazard;Quadratic hazard;詹砚营拂本原祸浇淘徽屏湿证绕凶潭标胡淘拈肮加赏叁贴昂箱少溺婉秒刺W7-9生存析W7-9生存析;Two sample comparison: Hypotheses;Organizing your data into contingency tables;Fisher’s exact test;Log Rank Test:Asymptotic Chi-square distribution;Assumptions;Weighted version: different weights proposed;Example: lung cancer;R code (taken from help documents for survdiff);Useful plots;Sample size calculation