ACEI心衰治疗—培训课件.pptVIP

* The patterns of adverse experiences leading to discontinuation of study medication differed in that valsartan, which had slightly greater blood pressure lowering, was more likely to be associated with hypotension or renal concerns, whereas captopril discontinuation was more frequently attributed to rash, cough, or taste disturbance. Combining therapies resulted in additive adverse experiences. Pfeffer, et al., NEJM 2003;349:1893-1906 * CCS-1：早期与远期病死率（%） 死亡原因 早期死亡率 死亡减少 远期死亡率 死亡减少 对照组 治疗组 1000人 对照组 治疗组 1000人 总病死率 9.6 9.0 6 8.3 7.0 * 13 心血管病 9.5 8.8 7 7.2 5.9 13 心力衰竭 2.5 1.9 6 3.6 2.6