羟基磷灰石胶原-魔芋葡甘聚糖多孔支架研究.PDFVIP

34 6 () http: //www. kustjourna.l com/ V o.l 34 N o6 2009 12 Journal of Kunm ing Un ivers ity of S cience and T echnology( Science and T echnology Dec. 2009 do:i 10. 3969 / j. issn. 1007- 855x. 2009. 06. 004 / - 1 1 1 2 1 陈寰贝, 洪东峰 , 雷 力, 潘兴华 , 陈庆华 ( 1 , 650093; 2 , 650032 : 采用共滴定法制备了羟基磷灰石/胶原复合粉体, 通过凝胶- 冷冻干燥法制备了羟基磷灰石/胶 原- 魔芋葡甘 糖多孔支架. 分析了碱加入量对支架显气孔率孔径及强度的影响. XRD 与TEM 结果 显示复合粉体中无机相为纳米羟基磷灰石. 所制备的支架显气孔率在 80% 以上, 抗压强度在 0. 45~ 1. 31M Pa, SEM 结果显示孔径分布在 100~ 300 m. 细胞相容性实验证明表明细胞在支架上生长良好. : 羟基磷灰石; 胶原; 魔芋葡甘 糖; 组织工程 : R 318. 08 : A : 1007- 855X ( 2009 06- 0019- 04 Study onHydroxyapatite/Collagen- onjac Glucomannan PorousComposite Scaffolds 1 1 1 2 1 CHEN H ua n-be i, HO NG Dong-feng , LE I L i , PAN X ing-hua , CHEN Q ing-hua ( 1Faculty o f M eta llurg ica l and Ene rgy Eng inee ring, K unm ing U niversity of Sc ience and T echno logy, Y unnan K unm ing 650093, China; 2R esearch Center of Stem Ce lls, T issue and O rgan Eng inee ring, K unm ing G eneralH o spita l o f Chengdu M ilita ry D istrict o f CPLA, K unm ing 6500 32, China Abstract:H ydroxyapat ite / co llagen com posite w as synthesized by smi ultaneou s titrat ion. Porous hydroxyapatite / co llagen- konjac g lucom annan scaffoldsw ere prepared by ge lation and freeze- drying m e thod. The amm on ia con- tent w as invest igated. It w as show n that nano- hydroxyapa tite w as the m ain ino rgan ic phase o f com posite by XRD and TEM and the porosity of the scaffo lds m ore than 80% , the com press streng th varied