解读《加拿大二膦酸盐相关性下颌骨坏死诊疗指南共识》.pdfVIP

236 中国骨质疏松杂志　2009 年 3 月第 15 卷第 3 期　Chin J Osteoporos , March 2009 ,Vol 15 , No. 3 ·译文· 解读《加拿大二膦酸盐相关性 下颌骨坏死诊疗指南共识》 周惠琼 ( ) 中图分类号: R24683 　　文献标识码 : A 　　文章编号 : 2009 摘要 : 随着二膦酸盐广泛地应用于治疗骨质疏松症、恶性肿瘤相关的骨骼疾病等 ,二膦酸盐引起的下 ( ) 颌骨坏死 ONJ 逐渐引起人们的关注 ,它是一种罕见而严重的并发症。为此 ,加拿大口腔及颌面外科 学会组织了国内外的多学科专家 ,通过对 ONJ 相关的文献进行了系统的复习 ,制定了二膦酸盐相关 性 ONJ 诊疗指南。目的为临床医生提供一个诊断、预防及治疗二膦酸盐相关性 ONJ 的建议。笔者翻 译了指南共识的相关内容 ,供临床医生参考。 关键词 : 骨坏死 ; 下颌骨 ; 双膦酸盐 Explanation of “Canadian Consensus Practice Guidelines for Bisphosphonate Associated Osteonecrosis of the Ja w”　ZHOU Huiqiong . Rheumatology and Immunology Department , ChinaJapan Friendship Hospital , Beijing 100029 , China Abstract : Osteoporosis is becoming more common nowadays. Bisphosphonates have become a cornerstone in the management of osteoporosis ,skeletal complications of malignancy and other metabolic bone disease. Though these agents offer great benefit to those with malignancy or metabolic bone disease ,there are some side effects reported regarding bisphosphonateassociated osteonecrosis of the jaw ( ONJ ) . The Canadian Association of Oral and Maxillofacial Surgeons ( CAOMS) in association with national and international societies reviewed the current reference of ONJ associated with bisphosphonate and developed recommendations regarding diagnosis ,identification of atrisk patients ,prevention and management strategies of ONJ caused by bisphosphonates. We here provided partial translation in Chinese from the original paper. Key words : Osteonecrosis ; Jaw ; Bisphosphonate 　　自从 2003 年第一例关于二膦酸盐引起下颌骨 料不多 ,很多患者因惧怕 ONJ 而停用二膦酸盐 ,从 ( ) 坏死 osteonecrosis of the jaw , ONJ 的报道发表后 ,二