支气管哮喘的诊断和的分级.pptVIP

支气管哮喘的诊断 及分级 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile . Copyright 2004-2011 Aspose Pty Ltd.  支气管哮喘一个全球性的公共卫生问题 全球哮喘患病率 新西兰:11% 澳洲 : 13.5% 太平洋岛屿：65% 中国:1%~5%* 中国估计有哮喘患者约3000万# 全球保守估计至少有哮喘患者1.3亿以上 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile . Copyright 2004-2011 Aspose Pty Ltd. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile . Copyright 2004-2011 Aspose Pty Ltd. 内容提要 疾病基础 诊断标准及鉴别诊断 分期及分级 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile . Copyright 2004-2011 Aspose Pty Ltd. 哮喘的定义 是由多种细胞，包括气道的炎性细胞和结构细胞（如：嗜酸粒细胞，肥大细胞，T淋巴细胞，中性粒细胞，平滑肌细胞，气道上皮细胞等）和细胞组分参与的气道慢性炎症性疾病 慢性炎症导致气道高反应性，通常出现广泛多变的可逆性气流受限 引起反复发作的喘息，气急，胸闷或咳嗽等症状，常在夜间和/或清晨发作、加剧。多数患者可自行缓解或经治疗后缓解 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile . Copyright 2004-2011 Aspose Pty Ltd. 哮喘发病机制 Global Initiative for Asthma (GINA). Revised 2006. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile . Copyright 2004-2011 Aspose Pty Ltd. 炎症是哮喘发病的核心 Global Initiative for Asthma (GINA). Revised 2006. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile . Copyright 2004-2011 Aspose Pty Ltd. 炎症细胞通过炎症介质介导的作用 炎症细胞 肥大细胞 嗜酸粒细胞 Th2 细胞 嗜碱粒细胞 中性粒细胞 血小板 结构细胞 上皮细胞 平滑肌细胞 内皮细胞 成纤维细胞 神经细胞 介质 组胺 白三烯类 前列腺素类 PAF 激肽类 腺苷 内皮缩血管肽类 一氧化氮 细胞因子 炎症趋化因子类 生长因子 效应 支气管痉挛 血浆渗出 黏液分泌 AHR 结构改变 Asthma and COPD (Second Edition), 2009, Pages 399-423 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile . Copyright 2004-2011 Aspose Pty Ltd. 急性炎症发作 时间 哮喘炎症发展过程 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile . Copyright 2004-2011 Aspose Pty Ltd. 哮喘的病理生理改变 Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile . Copyright 2004-2011 Aspose Pty Ltd. 气流受限的形式 Global Initiative for Asthma (GINA). Revised 2006. Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile .