孩子的手术适应症Retrobulbar dexmedetomidine decreases the MLAC of ropivacaine in vitreoretinal surgery in children.pdfVIP

Eur J Ophthalmol 2015; 25 (4): 352-356 EJO DOI: 10.5301/ejo.5000549 ISSN 1120-6721 ORIGINAL ARTICLE Retrobulbar dexmedetomidine decreases the MLAC of ropivacaine in vitreoretinal surgery in children 1 1,2 3 Weidi Ye , Zhiyong Hu , Xiuming Jin 1 Department of Anesthesiology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou - China 2 Department of Anesthesiology, The Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou - China 3 Department of Ophthalmology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou - China ABSTRACT Purpose: Dexmedetomidine can prolong the duration of local anesthetics, but the effect of retrobulbar dexme- detomidine on the potency of ropivacaine for retrobulbar block has not been investigated. Our study was de- signed to determine the effect of retrobulbar dexmedetomidine on ropivacaine for retrobulbar block in children. Methods: A group of 90 children aged 10-16 years scheduled for vitreoretinal surgery who received retrobulbar block were randomly assigned to 1 of 3 groups: group L (retrobulbar ropivacaine), group LD1 (ropivacaine plus 0.5 µg.kg-1 dexmedetomidine), or group LD2 (ropivacaine plus 1 µg.kg-1 dexmedetomidine). The minimum local anesthetic concentration (MLAC) was determined according to a Dixon-Massey protocol. The primary endpoint of the study was MLAC. Secondary outcomes were duration of postoperative analgesia, postoperative pain scores, dexmedetomidine side effects, and time to hospital discharge. Results: The MLAC values of retrobulbar ropivacaine were 0.314%, 0.259%, and 0.246% in groups L, LD1, and LD2, respect