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International Journal of Nanomedicine Dovepress
open access to scientific and medical research
Open Access Full Text Article O r I g I N A L r e s e A r c h
effect of interaction of magnetic nanoparticles
of Fe O and artesunate on apoptosis of K562 cells
3 4
Ying Wang 1 Abstract: The present study evaluated whether the magnetic nanoparticles of Fe O
3 4
Yuxiang han 1 (MNPs-Fe O ) could enhance the activity of artesunate (ART), and to explore its potential
3 4
Yingying Yang 1 mechanisms. Cytotoxicity of the copolymer of ART with MNPs-Fe3O4 on K562 cells was
Jingci Yang 1 detected by MTT assay and the apoptosis rate of K562 cells was measured by flow cytometry.
Xiaonan guo 1 Protein expression levels of bcl-2, bax, bcl-rambo, caspase-3, and survivin in K562 cells were
Jingnan Zhang 1 measured by Western blot. After being incubated with the copolymer of ART with MNPs-Fe3O4
1 for 48 hours, the growth inhibition rate of K562 cells was significantly increased compared
Ling Pan
guohua Xia2 with that of K562 cells treated with ART alone (P ,0.05), and the apoptosis rate of K562 cells
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