RANKL 南方医科大学(英文版).pdfVIP

Article Metformin stimulates osteoprotegerin and reduces RANKL expression in osteoblasts and ovariectomized rats Qiguang Mai1,2 , Zhongmin Zhang1,2, Song Xu1,2, Ming Lu1,2, Rongping Zhou1,2, Li Zhao3,4, Chunhong Jia3,4, Zhihua Wen3,4, Dadi Jin1,2, Xiaochun Bai2,3,4 1Department of Orthopedic, the Third Affiliated Hospital of Southern Medical University. Guangzhou 510665, China, 2Orthopedic Research Institute, Southern Medical University, Guangzhou 510515, China, 3Department of Cell Biology, School of Basic Medical science, Southern Medical University, Guangzhou 510515, China, 4Guangdong Provincial Key Laboratory for Regenerative Medicine of Bone Cartilage, Southern Medical University, Guangzhou 510515, China The first two authors contributed equally to this manuscript Corresponding to: Xiaochun Bai, Department of Cell Biology, School of Basic Medical science, Southern Medical University, Guangzhou, 510515, China (T: +86-20 F: +86-20 E-mail: baixc15@); Dadi Jin (T: +86-20 F: 86-20 E-mail: nyorthop@163.com ) Running title: Metformin regulates OPG and RANKL Received 28 January 2011; Revised 5 May 2011; Accepted 19 May 2011 Journal of Cellular Biochemistry © 2011 Wiley-Liss, Inc. DOI 10.1002/jcb.23206 1 ABSTRACT Anti-diabetic drug metformin has been shown to enhance osteoblasts differentiation and inhibit osteoclast differentiation in vitro and prevent bone loss in ovariectomized (OVX) rats. But the mechanisms through which metformin regulates