家族性复发性葡萄胎的临床特征及遗传学分析_赵峻.pdfVIP

2006 3 41 3　C hin J Ob tet Gyneco,l March 2006, V ol.41, N o.3 177 赵峻　向阳　黄尚志　万希润　董敏　胡韶毅　何莲芝　杨秀玉 　　【】　　(FRM )。　 2 FRM , 2 FRM 6 DNA , 。　2 FRM (B iCHM );6, 1 , 5 。 2 FRM , , (), 。　, FRM BiCHM, 。, 。 【】　;　;　() * C lin ical character istic s and gene tic ana ly ses of fam ilial recurren t m oles　　ZHAO J un , X IAN G Yang, H UAN G Shang-zh ,i WAN X -i run, DON G M in, HU Shao-y ,i HE Lian-zh i, YAN G X iu-yu. * D epartm en t o Obstetrics and Gy necology, P ek ing Un ion M ed ica l Colleg e H osp ita ,l P ek ing Un ion M ed ica l Colleg e, Ch ineseA cadem y o M ed ical S cience, B eij ing 100730, Ch ina Corresp ond ing au thor:X IAN G Yang, 100 730 D eparmt en t o Obstetrics and Gynecology, P ek ing Un ion M ed ical Colleg eH osp ital, P ek ing Un ion M ed ical Collehe, Ch inese Academ y o M ed ical S cience 【A b stract】　O b jective　To p robe the clin ical characteri tic and genetic orig in of fam ilial recurrent m ole (FRM ).M e thod s　Tw o ca e of FRM w ere reported retro pectively.M icro atellite polym orphi m w a u ed to determ ine the genetic orig in of the wt o FRM and other ix poradic m ole from other independent fam ilie .R esu lts　The wt o FRM patien t cam e from two independent fam ilie .Both of them had m ore than two time of hydatidiform mole and the am e condition had happened to the ir i ter .T he la t mole from each of the e two patient wa identified a biparental com plete hydatidiform mole (B iCHM ).Am ong the ix poradicm ole, one wa partial hydatidiform mole (PHM ), wh ich w a identified a trip lo id w ith one hap lo id m aternal et of chrom o om e and two hap lo id paternal et of chrom o om e .The other five porad ic mole w ere all androgenetic com plete hydatid iform mole (A nCHM ), wh ich lacked m aternal g eneticm aterial