乙型肝炎病毒母婴传播及阻断的相关因素探讨.pdfVIP

目录 英文缩略语表·············································3 中文摘要·················································4 英文摘要·················································6 前言·····················································9 正 文····················································11 1 材料和方法············································11 2 结果··················································12 3 讨论·················································20 4 结论················································25 参考文献··············································26 综述··················································29 2 万方数据 英文缩略语表 缩略词 英文全称 中文全称 ALT Alanine transaminase 丙氨酸氨基转移酶 DNA Deoxyribonucleic Acid 脱氧核糖核酸 ELISA Enzyme-linked immunosorbent assay 酶联免疫吸附实验 HBeAg Hepatitis B virus e antigen 乙肝病毒E 抗原 HBIG Hepatitis B immunoglobulin 乙型肝炎免疫球蛋白 HBsAg Hepatitis B virus surface antige 乙肝病毒表面抗原 HBV Hepatitis B virus 乙型肝炎病毒 PCR Polymerase chain reaction 聚合酶链反应 3 万方数据 中文摘要 【目的】 本研究拟通过对我市 HBsAg 阳性母亲及其所生婴幼儿进行深入的流行病 学调查，探索 HBV 母婴传播的现状和相关的危险因素，为预防和控制 HBV 在 母婴间传播提供线索和依据。 【方法】 本研究病例为2012 年 1 月～2012 年 12 月在我院产科住院分娩随访的 360 例无症状乙型肝炎病毒携带孕妇（总分娩数3008 例，其中HBsAg 阳性母亲总共 409 例，随访阳性率 13.60% ）及其婴幼儿360 例作为主要研究对象。针对其中 160 例 HBeAg(+)母亲根据孕晚期是否进行被动免疫注射 HBIG 分为注射 HBIG 组（40 例）和未注射HBIG 组（120 例），孕晚期注射HBIG 组中，分别于28 、 32、36 周开始各肌肉注射一次200 单位HB